Structure and function of haemoglobins

DA Gell - Blood Cells, Molecules, and Diseases, 2018 - Elsevier
Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Structure and regulation of soluble guanylate cyclase

ER Derbyshire, MA Marletta - Annual review of biochemistry, 2012 - annualreviews.org
Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …

The structure and function of plant hemoglobins

JA Hoy, MS Hargrove - Plant Physiology and Biochemistry, 2008 - Elsevier
Plants, like humans, contain hemoglobin. Three distinct types of hemoglobin exist in plants:
symbiotic, non-symbiotic, and truncated hemoglobins. Crystal structures and other structural …

Hemoglobins dioxygenate nitric oxide with high fidelity

PR Gardner, AM Gardner, WT Brashear… - Journal of Inorganic …, 2006 - Elsevier
Distantly related members of the hemoglobin (Hb) superfamily including red blood cell Hb,
muscle myoglobin (Mb) and the microbial flavohemoglobin (flavoHb) dioxygenate nitric …

Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins

M Milani, A Pesce, M Nardini, H Ouellet… - Journal of inorganic …, 2005 - Elsevier
Truncated hemoglobins (trHbs) are low-molecular-weight oxygen-binding heme-proteins
distributed in eubacteria, cyanobacteria, unicellular eukaryotes, and in higher plants …

Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR

E Fordel, E Geuens, S Dewilde, P Rottiers… - Biochemical and …, 2004 - Elsevier
The vertebrate globin family has been extended with two members: neuroglobin and
cytoglobin. We here investigate the changes of expression levels upon hypoxia of cytoglobin …

A phylogenetic and structural analysis of truncated hemoglobins

DA Vuletich, JTJ Lecomte - Journal of molecular evolution, 2006 - Springer
Truncated hemoglobins (trHbs) are heme proteins found in bacteria, plants, and unicellular
eukaryotes. They are distantly related to vertebrate hemoglobins and are typically shorter …

Theoretical study of the truncated hemoglobin HbN: exploring the molecular basis of the NO detoxification mechanism

A Crespo, MA Martí, SG Kalko, A Morreale… - Journal of the …, 2005 - ACS Publications
Mycobacterium tuberculosis is the causative agent of human tuberculosis. The nitric oxide
reaction with oxy-truncated hemoglobin N (trHbN) has been proposed to be responsible for …

Structural divergence and distant relationships in proteins: evolution of the globins

JTJ Lecomte, DA Vuletich, AM Lesk - Current opinion in structural biology, 2005 - Elsevier
The globin family has long been known from studies of∼ 150-residue proteins such as
vertebrate myoglobins and haemoglobins. Recently, this family has been enriched by the …

The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase

N Kumar, P Nakagawa, B Janic… - American Journal …, 2016 - journals.physiology.org
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural tetrapeptide with anti-
inflammatory and antifibrotic properties. Previously, we have shown that prolyl …