Nephrotic syndrome is defined by nephrotic-range proteinuria (≥ 40 mg/m2/hour or urine
protein/creatinine ratio≥ 200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (< …

Background: Steroid resistant nephrotic syndrome (SRNS) is a rare condition, accounting for
10–15% of all children with idiopathic nephrotic syndrome. SRNS can be caused by genetic …

The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns
of injury on kidney biopsies, but not specific to underlying pathobiology. Consequently, there …

Background Interstitial fibrosis (IF), tubular atrophy (TA) and interstitial inflammation (II) are
known determinants of progression of renal disease. Standardized quantification of these …

Clinical trials indicate that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i)
improve kidney function, yet, the molecular regulation of SGLT2 expression is incompletely …

Rationale & Objectives Glomerular diseases, including minimal change disease, focal
segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) …

Background Steroid-sensitive nephrotic syndrome (SSNS) is a childhood disease with
unclear pathophysiology and genetic architecture. We investigated the genomic basis of …

Importance Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage
kidney disease (ESKD) across the lifespan. While 10% to 15% of children and 3% of adults …

Rationale & Objective Remission of proteinuria has been shown to be associated with lower
rates of kidney disease progression among people with focal segmental glomerulosclerosis …

Random urine protein creatinine ratios are used to estimate 24-hour urine protein excretion,
which is considered a diagnostic gold standard. However, few studies are available of the …