As the gap between donors and patients in need of an organ transplant continues to widen,
research in regenerative medicine seeks to provide alternative strategies for treatment. One …

Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …

Liver synthetic and metabolic function can only be optimised by the growth of cells within a
supportive liver matrix. This can be achieved by the utilisation of decellularised human liver …

The process of evaluating the efficacy and toxicity of drugs is important in the production of
new drugs to treat diseases. Testing in humans is the most accurate method, but there are …

Discarded human donor organs have been shown to provide decellularized extracellular
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell …

With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Decellularization is the process of removing the cellular components from tissues or organs.
It is a promising technology for obtaining a biomaterial with a highly preserved extracellular …

The extracellular matrix is produced by the resident cells in tissues and organs, and
secreted into the surrounding medium to provide biophysical and biochemical support to the …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …