Objectives This report reviews the carcinogenicity of multi‐walled carbon nanotubes
(MWCNTs) in experimental animals, concentrating on MWNT‐7, a straight fibrous MWCNT …

In the deliberations over many years on the question of thresholds for the carcinogenicity of
chemicals, the dominant paradigm has been the linear no-threshold (LNT) model, derived …

Chemicals with carcinogenic activity in either animals or humans produce increases in
neoplasia through diverse mechanisms. One mechanism is reaction with nuclear DNA …

For genotoxic carcinogens, covalent binding to DNA is a critical initiating event in
tumorigenesis. The present research investigated dose-effect relationships of three …

Qualitative and quantitative approaches are important issues in field of carcinogenic risk
assessment of the genotoxic carcinogens. Herein, we provide quantitative data on low-dose …

Exposure to acrylonitrile induces formation of tumors at multiple sites in rats, with females
being more sensitive. The present study assessed possible mechanisms of acrylonitrile …

Male rats are more susceptible to the induction of liver cancer by the aromatic amine 2-
acetylaminofluorene (AAF) than are females. To assess the basis for this difference and to …

In vitro genotoxicity assays utilising human skin models are becoming important tools for the
safety assessment of chemicals whose primary exposure is via the dermal route. In order to …

The concept of thresholds for the carcinogenicity of chemicals has long been under
consideration and is widely accepted for carcinogens with an epigenetic mode of action …

A major cause of cancer in humans is exposure to mutagenic compounds. This raises the
question of how humans can be protected from these environmental mutagens. Bile …