The global preclinical antibacterial pipeline
Antibacterial resistance is a great concern and requires global action. A critical question is
whether enough new antibacterial drugs are being discovered and developed. A review of …
whether enough new antibacterial drugs are being discovered and developed. A review of …
Bacteria-cancer interactions: bacteria-based cancer therapy
MTQ Duong, Y Qin, SH You, JJ Min - Experimental & molecular …, 2019 - nature.com
Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …
have raised the hope for cures for many cancer types. However, there are still ongoing …
Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis
X Yan, XY Liu, D Zhang, YD Zhang, ZH Li… - Cellular & Molecular …, 2021 - nature.com
Colitis is a common disease of the colon that is very difficult to treat. Probiotic bacteria could
be an effective treatment. The probiotic Escherichia coli Nissle 1917 (EcN) was engineered …
be an effective treatment. The probiotic Escherichia coli Nissle 1917 (EcN) was engineered …
Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere
Microcins are low-molecular-weight, ribosomally produced, highly stable, bacterial-inhibitory
molecules involved in competitive, and amensalistic interactions between …
molecules involved in competitive, and amensalistic interactions between …
Intratumor microbiome in cancer progression: current developments, challenges and future trends
J Liu, Y Zhang - Biomarker Research, 2022 - Springer
Cancer is a complicated disease attributed to multifactorial changes, which causes
difficulties with treatment strategies. Various factors have been regarded as the main …
difficulties with treatment strategies. Various factors have been regarded as the main …
Synthetic systems powered by biological molecular motors
Biological molecular motors (or biomolecular motors for short) are nature's solution to the
efficient conversion of chemical energy to mechanical movement. In biological systems …
efficient conversion of chemical energy to mechanical movement. In biological systems …
Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development
N Zhao, Y Song, X ** synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …
and engineer cells for improved performance, novel functions, and diverse applications …
Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron
Bacteroides thetaiotaomicron is a human-associated bacterium that holds promise for
delivery of therapies in the gut microbiome. Therapeutic bacteria would benefit from the …
delivery of therapies in the gut microbiome. Therapeutic bacteria would benefit from the …
Engineering probiotics for therapeutic applications: recent examples and translational outlook
Highlights•Probiotics can be engineered to develop live biotherapeutics in case of no
efficacy of the wild-type strains.•Probiotics have been engineered to treat diseases such as …
efficacy of the wild-type strains.•Probiotics have been engineered to treat diseases such as …
Coculture of primary human colon monolayer with human gut bacteria
The presence of microbes in the colon impacts host physiology. Therefore, microbes are
being evaluated as potential treatments for colorectal diseases. Humanized model systems …
being evaluated as potential treatments for colorectal diseases. Humanized model systems …