Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

Efficacy and Safety of Encaleret in Autosomal Dominant Hypocalcemia Type 1 | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Key Clinical Points Hypoparathyroidism Hypoparathyroidism is a rare disease that results in
hypocalcemia. Symptoms, when present, range from paresthesias and muscle cramps to …

The extracellular calcium (Ca 2+ o)-sensing receptor (CaSR) is a family CG protein-coupled
receptor, which detects alterations in Ca 2+ o concentrations and modulates parathyroid …

The role of the kidney in calcium homeostasis has been reshaped from a classic view in
which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or …

The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The diseases …

Calcium and phosphate are critical to human physiology (eg, neuromuscular function) and
are also needed for skeletal mineralization. An understanding of calcium and phosphate …

Calcium is vital for life, and extracellular calcium concentrations must constantly be
maintained within a precise concentration range. Low serum calcium (hypocalcemia) occurs …

The actions of extracellular Ca 2+ in regulating parathyroid gland and kidney functions are
mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor. The …