Harnessing the power of the human immune system to treat cancer is the essence of
immunotherapy. Monoclonal antibodies engage the innate immune system to destroy …

Control of structural flexibility is essential for the proper functioning of a large number of
proteins and multiprotein complexes. At the residue level, such flexibility occurs due to local …

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved
molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in …

Revealing antibody-antigen interactions at the single-molecule level will deepen our
understanding of immunology. However, structural determination under crystal or cryogenic …

The precise spatial localization of proteins in situ by super-resolution microscopy (SRM)
demands their targeted labeling. Positioning reporter molecules as close as possible to the …

Complement activation through antibody–antigen complexes is crucial in various
pathophysiological processes and utilized in immunotherapies to eliminate infectious …

Commonly used methods for determining protein structure, including X-ray crystallography
and single-particle reconstruction, often provide a single and unique three-dimensional (3D) …

ABSTRACT A large body of data exists demonstrating that neonatal Fc receptor (FcRn)
binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG …

Binding of antibodies to their cognate antigens is fundamental for adaptive immunity.
Molecular engineering of antibodies for therapeutic and diagnostic purposes emerges to be …

We define multivalency to be the operation of multiple molecular recognition events of the
same kind occurring simultaneously between two entities (molecules, molecular aggregates …