Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Recent theoretical accounts have proposed excitation and inhibition (E/I) imbalance as a
possible mechanistic, network-level hypothesis underlying neural and behavioral …

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high
human and economic burden. The pathophysiology of ASD is largely unclear, thus …

Evidence suggests that neurometabolite alterations may be involved in the pathophysiology
of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic …

Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …

Changes in the gut microenvironment may influence the pathogenesis of autism spectrum
disorders (ASD). Here, we investigated the composition of the gut microbiota and …

Cannabis-derived compounds, such as cannabidiol (CBD) and delta-9-trans-
tetrahydrocannabinol (THC), are increasingly prescribed for a range of clinical indications …

Currently, there are no effective pharmacologic treatments for the core symptoms of autism
spectrum disorder (ASD). There is, nevertheless, potential for progress. For example, recent …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Current evidence-based pharmacotherapy options in children with ASD are very limited, and
many have substantial adverse events. Clinicians should use pharmacotherapy as a part of …