The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …

We have recently reported that Notch 1, a member of the Notch multigene family, is essential
for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated …

Although transcriptional programs associated with T-cell specification and commitment have
been described, the functional hierarchy and the roles of key regulators in structuring …

Like all hematopoietic cells, T lymphocytes are derived from bone-marrow-resident stem
cells. However, whereas most blood lineages are generated within the marrow, the majority …

Some γδ and αβ T lymphocytes exhibit an “innate” phenotype associated with rapid cytokine
responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells …

Signals transduced by Notch receptors are indispensable for T cell specification and
differentiation of αβ T lineage cells. However, the role of Notch signals during αβ versus γδ T …

For many years, researchers have focused on the contribution of Notch signalling to
lymphoid development. Only recently have investigators begun to ask what role, if any …