DNA G-quadruplex in human telomeres and oncogene promoters: structures, functions, and small molecule targeting
Conspectus DNA G-quadruplex secondary structures formed in guanine-rich human
telomeres and oncogene promoters are functionally important and have emerged as a …
telomeres and oncogene promoters are functionally important and have emerged as a …
G-quadruplexes and their ligands: Biophysical methods to unravel G-quadruplex/ligand interactions
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …
approaches that assess the binding mode and nature of the interactions between G4 …
G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions
C Esnault, T Magat, A Zine El Aabidine… - Nature …, 2023 - nature.com
Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy
PA Summers, BW Lewis, J Gonzalez-Garcia… - Nature …, 2021 - nature.com
Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-
quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and …
quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and …
Unlocking G-quadruplexes as antiviral targets
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
Structure of an RNA G-quadruplex from the West Nile virus genome
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …
Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome
M Tassinari, SN Richter, P Gandellini - Nucleic Acids Research, 2021 - academic.oup.com
Noncoding RNAs are functional transcripts that are not translated into proteins. They
represent the largest portion of the human transcriptome and have been shown to regulate …
represent the largest portion of the human transcriptome and have been shown to regulate …
[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …
acids have great potential as selective drugs or as tools in drug target discovery programs …
Advances and challenges in identifying and characterizing G-quadruplex–protein interactions
Y Dai, X Teng, Q Zhang, H Hou, J Li - Trends in Biochemical Sciences, 2023 - cell.com
G-quadruplexes (G4s) are peculiar nucleic acid secondary structures formed by DNA or
RNA and are considered as fundamental features of the genome. Many proteins can …
RNA and are considered as fundamental features of the genome. Many proteins can …