Advances in the chemistry of redox-active bis (imino) acenaphthenes (BIAN): A case of transition metal complexes

IS Fomenko, NF Romashev, AL Gushchin - Coordination Chemistry …, 2024 - Elsevier
The chemistry of redox-active bis (imino) acenaphthenes (BIAN, R-bian) and metal
complexes based on them has been a rapidly develo** field since the 1990s. The key …

Metal complexes of thiosemicarbazones for imaging and therapy

JR Dilworth, R Hueting - Inorganica Chimica Acta, 2012 - Elsevier
This review gives an account of the coordination chemistry of thiosemicarbazone ligands
with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and …

In vitro and in vivo anticancer activity of copper bis (thiosemicarbazone) complexes

D Palanimuthu, SV Shinde… - Journal of medicinal …, 2013 - ACS Publications
Neutral and cationic copper bis (thiosemicarbazone) complexes bearing methyl, phenyl, and
hydrogen, on the diketo-backbone of the ligand have been synthesized. All of them were …

Synthesis, characterization, and in vitro anticancer activity of copper and zinc bis (thiosemicarbazone) complexes

R Anjum, D Palanimuthu, DS Kalinowski… - Inorganic …, 2019 - ACS Publications
A series of eight bis (thiosemicarbazone) ligands and 16 of their respective copper (II) and
zinc (II) complexes containing a combination of hydrogen, methyl, pyridyl, phenyl, and/or …

Zinc (II)–thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity

AE Stacy, D Palanimuthu, PV Bernhardt… - Journal of medicinal …, 2016 - ACS Publications
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …

Hint from an enzymatic reaction: superoxide dismutase models efficiently suppress colorectal cancer cell proliferation

H Lim, C Oh, MS Park, HB Park, C Ahn… - Journal of the …, 2023 - ACS Publications
Superoxide dismutases (SODs) are essential antioxidant enzymes that prevent massive
superoxide radical production and thus protect cells from damage induced by free radicals …

[HTML][HTML] Synthesis of carvacrol derivatives as potential new anticancer agent against lung cancer

A Bansal, MM Saleh-E-In, P Kar, A Roy, NR Sharma - Molecules, 2022 - mdpi.com
Lung cancer remains a major public health concern among all cancer diseases due to the
toxicity and side-effects of the available commercially synthesized drugs. Natural product …

Mixed ligand copper (II)-diimine complexes of 2-formylpyridine-N 4-phenylthiosemicarbazone: Diimine co-ligands tune the in vitro nanomolar cytotoxicity

R Kartikeyan, D Murugan, T Ajaykamal… - Dalton …, 2023 - pubs.rsc.org
Recently, mixed-ligand copper (II) complexes have received much attention in searching for
alternative metallodrugs to cisplatin. A series of mixed ligand Cu (II) complexes of the type …

Synthesis, structure and in vitro pharmacological evaluation of a novel 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde (2′-methylbenzoyl) hydrazone bridged copper (II) …

DS Raja, E Ramachandran, NSP Bhuvanesh… - European Journal of …, 2013 - Elsevier
A novel ligand bridged copper (II) coordination polymer,[Cu (HL)(NO3)] n has been
synthesized by reacting 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde (2′-methylbenzoyl) …

Identification of differential anti-neoplastic activity of copper bis (thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and …

C Stefani, Z Al-Eisawi, PJ Jansson… - Journal of inorganic …, 2015 - Elsevier
Bis (thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic
properties. However, their mechanism of action remains unclear. We examined the structure …