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Extracellular nucleotides and nucleosides promote a vast range of physiological responses,
via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit …

Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

This review highlights recent findings that describ how purines modulate the physiological
and pathophysiological responses of ocular tissues. For example, in lacrimal glands the …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …

Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal
ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one …

In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in
the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens …

BACKGROUND: Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …

The urothelium is a newly recognized sensory structure that detects bladder fullness. Pivotal
to this sensory role is the release of ATP from the urothelium. However, the routes for …