The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …

Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …

Background Temozolomide (TMZ) is the preferred chemotherapy strategy for glioma
therapy. As a second-generation alkylating agent, TMZ provides superior oral bio …

Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …

Objective. Glioblastoma is one of the most common malignant tumors in the brain, and these
glioblastoma patients have very poor prognosis. Ferroptosis is involved in the progression of …

Abstract Background Glioblastoma multiforme (GBM, World Health Organization [WHO]
grade IV) is one of the malignant Central Nerve System (CNS) tumors with high incidence …

Glioblastoma is one of the most frequent malignant tumors derived from the brain in adults
with very poor prognosis. Ferroptosis is implicated in the initiation and progression of …

Several different signaling pathways and molecular mechanisms have been identified as
responsible for controlling critical functions in human cancer cells, such as selective growth …