Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Objective Gut microbiota may promote positive energy balance; however, germfree mice can
be either resistant or susceptible to diet-induced obesity (DIO) depending on the type of …

Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver
disease, and cancer. It is also linked with more severe complications from infections …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Dietary fibers are considered beneficial nutrients for health. Current data suggest that their
interaction with the gut microbiota largely contributes to their physiological effects. In this …

Diabetic kidney disease (DKD) is a leading cause of end stage renal disease with unmet
clinical demands for treatment. Lipids are essential for cell survival; however, renal cells …

A growing bulk of evidence suggests that cholesterol oxidation products, known as
oxysterols, are potentially involved in the pathogenesis of major chronic diseases, including …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …