Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular
disease is a leading cause of death worldwide. However, the cellular and molecular …

The vasculature is increasingly recognized to impact brain function in health and disease
across the life span. During embryonic brain development, angiogenesis and neurogenesis …

The human blood-brain barrier (hBBB) is a highly specialized structure that regulates
passage across blood and central nervous system (CNS) compartments. Despite its critical …

An important challenge in the chronic wound healing of diabetes is delayed healing stages
with impaired cellular functions, attributed to mitochondrial dysfunction and excessive …

Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar
degeneration (FTLD). While previous studies implicate aberrant microglial activation as a …

Angelman syndrome (AS), an early-onset neurodevelopmental disorder characterized by
abnormal gait, intellectual disabilities, and seizures, occurs when the maternal allele of the …

Meningiomas are the most common primary intracranial tumors. Treatments for patients with
meningiomas are limited to surgery and radiotherapy, and systemic therapies remain …

Radiation therapy is crucial in combating malignant tumors, yet its damage to the
microvascular system can significantly impair patient recovery and prognosis. Although …

Angiogenesis and neurogenesis are functionally interconnected during brain development.
However, the study of the vasculature has trailed other brain cell types because they are …