Microbial valorization of lignin toward coumarins: Challenges and perspectives
Lignin is the largest renewable aromatic resource in nature, while aromatic natural products,
coumarins, are part of a large family of plant secondary metabolites with many …
coumarins, are part of a large family of plant secondary metabolites with many …
Plant pyranocoumarins: Description, biosynthesis, application
MT Khandy, AK Sofronova, TY Gorpenchenko… - Plants, 2022 - mdpi.com
This overview article contains information about pyranocoumarins over the last 55 years.
The article is based on the authors' phytochemical and physiological studies in vivo and in …
The article is based on the authors' phytochemical and physiological studies in vivo and in …
The gradual establishment of complex coumarin biosynthetic pathway in Apiaceae
XC Huang, H Tang, X Wei, Y He, S Hu, JY Wu… - Nature …, 2024 - nature.com
Complex coumarins (CCs) represent characteristic metabolites found in Apiaceae plants,
possessing significant medical value. Their essential functional role is likely as protectants …
possessing significant medical value. Their essential functional role is likely as protectants …
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges
Covering: up to October 2020 Furanocoumarins are plant secondary metabolites used to
treat several skin disorders, such as psoriasis and vitiligo, and also with other potential …
treat several skin disorders, such as psoriasis and vitiligo, and also with other potential …
Synthetic and biosynthetic methods for selective cyclisations of 4, 5-epoxy alcohols to tetrahydropyrans
JI Bowen, L Wang, MP Crump, CL Willis - Organic & Biomolecular …, 2022 - pubs.rsc.org
Tetrahydropyrans (THPs) are common structural motifs found in natural products and
synthetic therapeutic molecules. In Nature these 6-membered oxygen heterocycles are often …
synthetic therapeutic molecules. In Nature these 6-membered oxygen heterocycles are often …
Computational Exploration of How Enzyme **mE Converts Natural S-Epoxide to Pyran and R-Epoxide to Furan
Enzymes have long been characterized for their specificity and efficiency in catalyzing one
substrate to one product. However, a SnoaL-like cyclase (**mE) that was originally …
substrate to one product. However, a SnoaL-like cyclase (**mE) that was originally …
Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli
Coumarins and furanocoumarins are plant secondary metabolites with known biological
activities. As they are present in low amounts in plants, their heterologous production …
activities. As they are present in low amounts in plants, their heterologous production …
Furanocoumarins from Heracleum persicum L.: Unveiling their biosynthesis and gene expression
Due to the high value of Persian angelica (Heracleum persicum L.) and the limited genetic
information regarding this plant, the investigation of the main secondary metabolites and …
information regarding this plant, the investigation of the main secondary metabolites and …
A fungal promiscuous UbiA prenyltransferase expands the structural diversity of chrodrimanin-type meroterpenoids
K Zhang, G Zhang, X Hou, C Ma, J Liu, Q Che… - Organic …, 2022 - ACS Publications
Prenyltransferases play important roles in the diversification of natural products and the
improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate …
improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate …
Modifications of Prenyl Side Chains in Natural Product Biosynthesis
In recent years, there has been a growing interest in understanding the enzymatic
machinery responsible for the modifications of prenyl side chains and elucidating their roles …
machinery responsible for the modifications of prenyl side chains and elucidating their roles …