The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele
nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion …

The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane
proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary …

Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …

Asian populations are under-represented in human genomics research. Here, we
characterize clinically significant genetic variation in 9051 genomes representing East …

Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance
and are associated with increased risk of cardiovascular events that manifest from statin …

Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Statins, the most widely used lipid-lowering drugs, are increasingly recognized to have
pleiotropic effects including anti-inflammatory and antiangiogenic properties as well as …

Low drug adherence is a major obstacle to the benefits of pharmacotherapies and it is
therefore important to identify factors associated with discontinuing or being poorly adherent …

The synergy of artificial intelligence and personalized medicine for the enhanced diagnosis,
treatment, and prevention of disease Skip to content Should you have institutional access …