TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

LW Shen, HJ Mao, YL Wu, Y Tanaka, W Zhang - Biochimie, 2017 - Elsevier
Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major …

Development and effects of influenza antiviral drugs

H Yin, N Jiang, W Shi, X Chi, S Liu, JL Chen, S Wang - Molecules, 2021 - mdpi.com
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal
outbreaks each year and unpredictable pandemics occasionally with high morbidity and …

Structural basis of SARS-CoV-2–and SARS-CoV–receptor binding and small-molecule blockers as potential therapeutics

H Sivaraman, SY Er, YK Choong… - Annual Review of …, 2021 - annualreviews.org
Over the past two decades, deadly coronaviruses, with the most recent being the severe
acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have …

Zinc finger CCCH-type antiviral protein 1 restricts the viral replication by positively regulating type I interferon response

B Zhang, MU Goraya, N Chen, L Xu, Y Hong… - Frontiers in …, 2020 - frontiersin.org
Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) is a host antiviral factor that can
repress translation and promote degradation of specific viral mRNAs. In this study, we found …

The contribution of viral proteins to the synergy of Influenza and bacterial co-infection

M Mikušová, K Tomčíková, K Briestenská… - Viruses, 2022 - mdpi.com
A severe course of acute respiratory disease caused by influenza A virus (IAV) infection is
often linked with subsequent bacterial superinfection, which is difficult to cure. Thus …

Molecular Markers and Mechanisms of Influenza A Virus Cross-Species Transmission and New Host Adaptation

X Guo, Y Zhou, H Yan, Q An, C Liang, L Liu, J Qian - Viruses, 2024 - mdpi.com
Influenza A viruses continue to be a serious health risk to people and result in a large-scale
socio-economic loss. Avian influenza viruses typically do not replicate efficiently in …

[PDF][PDF] Different mechanisms of the protection against influenza A infection mediated by broadly reactive HA2-specific antibodies

K Tomčíková, E Varečková - Acta Virol, 2019 - researchgate.net
Influenza A viruses (IAVs) cause yearly repeating infections in humans. The current
vaccination approach is based on the production of virus-neutralizing antibodies. Virus …

Biological properties of influenza A virus mutants with amino acid substitutions in the HA2 glycoprotein of the HA1/HA2 interaction region

L Jakubcová, M Vozárová, J Hollý… - Journal of General …, 2019 - microbiologyresearch.org
Influenza A viruses (IAVs) enter into cells by receptor-dependent endocytosis. Subsequently,
conformational changes of haemagglutinin are triggered by low environmental pH and the N …

A novel serological assay for influenza based on DiD fluorescence dequenching that is free from observer bias and potentially automatable–A proof of concept study

AI Makarkov, AR Patel, V Bainov, BJ Ward - Vaccine, 2018 - Elsevier
Background Serum hemagglutination inhibition (HAI) and microneutralization (MN)
antibodies are often used as a correlate of protection for influenza. However, these manual …

Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia

AF Ospina Jimenez - repositorio.unal.edu.co
El Virus de Influenza A (VIA) en cerdos ocasiona infección respiratoria y se asocia al
Complejo Respiratorio Porcino, generando impacto económico y sanitario. En Colombia, la …