Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Hemostasis and pathological thrombus formation are dynamic processes that require a co-
ordinated series of events involving platelet membrane receptors, bidirectional intracellular …

Platelets, monocytes, and endothelial cells are instrumental in the development and
progression of cardiovascular diseases. Inflammation, a key process underlying …

Blood platelets are anucleated circulating cells that play a critical role in hemostasis and are
also implicated in arterial thrombosis, a major cause of death worldwide. The biological …

Platelets contain unspliced heteronuclear IL-1β RNA, which is rapidly spliced and translated
upon activation. LPS is a superior agonist for this atypical platelet response, but how LPS …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

In vivo mouse models have indicated that the intrinsic coagulation pathway, initiated by
factor XII, contributes to thrombus formation in response to major vascular damage. Here, we …

Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …