Bacterial toxin-antitoxin systems' cross-interactions—implications for practical use in medicine and biotechnology

L Boss, B Kędzierska - Toxins, 2023 - mdpi.com
Toxin-antitoxin (TA) systems are widely present in bacterial genomes. They consist of stable
toxins and unstable antitoxins that are classified into distinct groups based on their structure …

[HTML][HTML] Bacterial toxin-antitoxin systems: Novel insights on toxin activation across populations and experimental shortcomings

LR Pizzolato-Cezar, B Spira, MT Machini - Current research in microbial …, 2023 - Elsevier
The alarming rise in hard-to-treat bacterial infections is of great concern to human health.
Thus, the identification of molecular mechanisms that enable the survival and growth of …

Programmed Death of Injured Pseudomonas aeruginosa on Mechano-Bactericidal Surfaces

S Zhao, Z Li, DP Linklater, L Han, P **, L Wen… - Nano Letters, 2022 - ACS Publications
Mechano-bactericidal surfaces deliver lethal effects to contacting bacteria. Until now, cell
death has been attributed to the mechanical stress imparted to the bacterial cell envelope by …

Synergistic antibacterial activity of gold nanoparticles caused by apoptosis‐like death

B Lee, DG Lee - Journal of applied microbiology, 2019 - academic.oup.com
Aims Metal nanoparticles are promising materials for the management of infectious diseases
as known to have various antimicrobial activities in pathogenic micro‐organisms. Among …

Salmonella Enteritidis antitoxin DinJ inhibits NLRP3-dependent canonical inflammasome activation in macrophages

D Gu, A Li, X Zang, T Huang, Y Guo, X Jiao… - Infection and …, 2024 - journals.asm.org
The inflammasome is a pivotal component of the innate immune system, acting as a
multiprotein complex that plays an essential role in detecting and responding to microbial …

[HTML][HTML] Involvement of RNA chaperone hfq in the regulation of antibiotic resistance and virulence in Shigella sonnei

Y Wang, Y Teng, J Geng, J Long, H Yang, G Duan… - Research in …, 2023 - Elsevier
The host factor for RNA phage Qβ replicase (Hfq) is a crucial post-transcriptional regulator in
many bacterial pathogens, facilitating the interaction between small non-coding RNAs …

Molecular mechanism of Hfq-dependent sRNA1039 and sRNA1600 regulating antibiotic resistance and virulence in Shigella sonnei

Y Du, Y Wang, J Geng, J Long, H Yang, G Duan… - International Journal of …, 2024 - Elsevier
Bacillary dysentery caused by Shigella spp. is a significant concern for human health. Small
non-coding RNA (sRNA) plays a crucial role in regulating antibiotic resistance and virulence …

[HTML][HTML] A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery

JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …

Plausible role of bacterial toxin–antitoxin system in persister cell formation and elimination

P Paul, BR Sahu, M Suar - Molecular Oral Microbiology, 2019 - Wiley Online Library
Although, a large proportion of pathogenic bacteria gets eliminated from hosts after antibiotic
treatment, a fraction of population confronts against such effects and undergoes growth …

Molecular insight to influential role of Hha–TomB toxin–antitoxin system for antibacterial activity of biogenic silver nanoparticles

P Paul, SK Verma, P Kumar Panda… - Artificial Cells …, 2018 - Taylor & Francis
Emergence of silver nanoparticles (AgNPs) as a potent antibacterial agent for clinical
application has raised attention towards its mode of action and needs detailed …