Depression is one of the leading causes of morbidity and mortality globally and in the United
States. 1 Depression affects individuals of all ages. 2 Among adolescents aged 13 to 18, the …

Introduction Prevention and treatment of pain in pediatric patients compared with adults is
often not only inadequate but also less often implemented the younger the children are …

Background Cannabis use is associated with increased risk of later psychotic disorder but
whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of …

Background The risk of individuals having adverse effects from drug use (eg, alcohol)
generally depends on the frequency of use and potency of the drug used. We aimed to …

Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented
phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different …

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the
reasons for this remain debated. Methods: We applied a Cox proportional hazards model to …

Background: There is a growing liberalization of cannabis-based preparations for medical
and recreational use. In multiple instances, anxiety and depression are cited as either a …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …

Cannabis remains the most commonly used and trafficked illicit drug in the world. Its use is
largely concentrated among young people (15-to 34-year-olds). There is a variety of …