Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …

Background. Quantitative reviews of postoperative pain management have demonstrated
that the number of patients needed to treat for one patient to achieve at least 50% pain relief …

The American College of Critical Care Medicine (ACCM), which honors individuals for their
achievements and contributions to multidisciplinary critical care medicine, is the consultative …

In order to be approved for marketing in the United States, drugs must be proven to be safe
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …

Background: Although laparoscopic cholecystectomy (LC) results in less pain than open
chole‐cystectomy, it is not a pain‐free procedure. Many methods of analgesia for pain after …

Background. Ketorolac is approved for the relief of postoperative pain but concerns have
been raised over a possible risk of serious adverse effects and death. Two regulatory …

Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) can play a major role in the
management of acute pain in the peri‐operative period. However, there are conflicting views …

Sports medicine physicians often treat athletes in pain with non-steroidal anti-inflammatory
drugs (NSAIDs). However, there is a lack of high-quality evidence to guide NSAID use. Their …

Background This study examined the opioid-sparing effectiveness, analgesic efficacy, and
tolerability of postoperative administration of the parenteral cyclooxygenase 2 selective …

This article summarizes the results of a meeting convened by the Initiative on Methods,
Measurement, and Pain Assessment in Clinical Trials (IMMPACT) on key considerations …