[HTML][HTML] NMR spectroscopy for metabolomics research
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …
three principal analytical techniques used in metabolomics (the other two being gas …
Metabolomics in diabetes and diabetic complications: insights from epidemiological studies
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
Genome-wide characterization of circulating metabolic biomarkers
Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …
Metabolomic profiles predict individual multidisease outcomes
Risk stratification is critical for the early identification of high-risk individuals and disease
prevention. Here we explored the potential of nuclear magnetic resonance (NMR) …
prevention. Here we explored the potential of nuclear magnetic resonance (NMR) …
Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank
Blood lipids and metabolites are markers of current health and future disease risk. Here, we
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from …
Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA),
there is still substantial controversy and uncertainty on the evidence linking PUFA to …
there is still substantial controversy and uncertainty on the evidence linking PUFA to …
[HTML][HTML] Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning
Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients' lives.
However, our understanding of biomarkers driving OA risk remains limited. We developed a …
However, our understanding of biomarkers driving OA risk remains limited. We developed a …
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population
Biomarkers of low-grade inflammation have been associated with susceptibility to a severe
infectious disease course, even when measured prior to disease onset. We investigated …
infectious disease course, even when measured prior to disease onset. We investigated …