Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer's disease
Background: Alzheimer's disease (AD) is an advanced and irreversible degenerative
disease of the brain, recognized as the key reason for dementia among elderly people. The …
disease of the brain, recognized as the key reason for dementia among elderly people. The …
Discovery of novel hybrids containing clioquinol− 1-benzyl-1, 2, 3, 6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease
Based on the multitarget strategy, a series of novel clioquinol− 1-benzyl-1, 2, 3, 6-
tetrahydropyridine hybrids were identified for the potential treatment of Alzheimer's disease …
tetrahydropyridine hybrids were identified for the potential treatment of Alzheimer's disease …
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer's Disease
X Wu, X Ze, S Qin, B Zhang, X Li, Q Gong, H Zhang… - Molecules, 2024 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative disease that can lead to the loss
of cognitive function. The progression of AD is regulated by multiple signaling pathways and …
of cognitive function. The progression of AD is regulated by multiple signaling pathways and …
Novel and Potent Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease from Natural (±)-7, 8-Dihydroxy-3-methyl-isochroman-4-one
Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive
decline as well as behavioral problems. It is a progressive and well recognized complex …
decline as well as behavioral problems. It is a progressive and well recognized complex …
Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets
Extensive research has been dedicated to develop compounds that can target multiple
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …