Fluorine is the most electronegative element in the periodic table. When bound to carbon it
forms the strongest bonds in organic chemistry and this makes fluorine substitution attractive …

Organofluorine compounds are widely used in many different applications, ranging from
pharmaceuticals and agrochemicals to advanced materials and polymers. It has been …

Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and
reactivity of organic molecules An advanced textbook that provides an up-to-date overview …

The ubiquity of per‐and polyfluoroalkyl substances (PFAS) has become an emerging
challenge for modern water treatment and public health. The development of high …

Transforming the fluorine gauche effect from an academic curiosity into a powerful acyclic
conformational control strategy has enriched molecular design. This expansive approach to …

The regio‐and enantio‐selective, intermolecular vicinal fluoroamination of α‐trifluoromethyl
styrenes has been achieved by enantioselective II/IIII catalysis. Leveraging C2‐symmetric …

Molecular design strategies that profit from the intrinsic stereoelectronic and electrostatic
effects of fluorinated organic molecules have mainly been restricted to bio‐organic …

Organofluorine compounds 1 have found increasing applications in key industrial fields
such as the pharmaceutical 2 and medicinal chemistry 3 or crop 4 and material sciences, 5 …

This review outlines the role of hyperconjugative interactions in the structure and reactivity of
organic molecules. After defining the common hyperconjugative patterns, we discuss the …

The introduction of fluorine atoms into molecules and materials across many fields of
academic and industrial research is now commonplace, owing to their unique properties. A …