There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-map** studies and …

A central challenge in evolutionary biology is to identify genes underlying ecologically
important traits and describe the fitness consequences of naturally occurring variation at …

As overwhelmingly demonstrated by the sequencing papers in this issue, the complete
anatomy of the human genome is now before us. In a very short time—within a decade—we …

Unraveling the evolutionary forces responsible for variations of neutral substitution patterns
among taxa or along genomes is a major issue in the identification of functional sequence …

One of the most striking findings to emerge from the study of genomic patterns of variation is
that regions with lower recombination rates tend to have lower levels of intraspecific diversity …

Over the last 15 years quantitative trait locus (QTL) map** has become a popular method
for understanding the genetic basis of continuous variation in a variety of systems. For …

In humans, most germline mutations are inherited from the father. This observation has been
widely interpreted as reflecting the replication errors that accrue during spermatogenesis. If …

Rates of recombination vary considerably between species. Despite the significance of this
observation for evolutionary biology and genetics, the evolutionary mechanisms that …

Comparative genome analyses, including chromosome painting in over 40 diverse
mammalian species, ordered gene maps from several representatives of different …

Levels of diversity vary across the human genome. This variation is caused by two forces:
differences in mutation rates and the differential impact of natural selection. Pertinent to the …