This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic,,,,. Studies of sensory neurons …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …

Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress,
and this supports an antiinflammatory phenotype. High laminar shear stress also induces …