Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development

WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Y Oe, X Wang, T Patriarchi, A Konno, K Ozawa… - Nature …, 2020 - nature.com
Astrocytes may function as mediators of the impact of noradrenaline on neuronal function.
Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca2+ elevation and …

The principle of conformational signaling

P Tompa - Chemical Society Reviews, 2016 - pubs.rsc.org
Signal transduction is the primary process by which cells respond to changes in their
physical and chemical environments. Cellular response is initiated through a signaling …

Absolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification

F Bierbuesse, AC Bourges, V Gielen… - Nature …, 2022 - nature.com
Genetically-encoded biosensors based on a single fluorescent protein are widely used to
visualize analyte levels or enzymatic activities in cells, though usually to monitor relative …

Concentration dependence of Förster resonant energy transfer between donor and acceptor nanocrystal quantum dot layers: Effect of donor-donor interactions

M Lunz, AL Bradley, VA Gerard, SJ Byrne… - Physical Review B …, 2011 - APS
The influences of donor and acceptor concentrations on Förster resonant energy transfer
(FRET) in a separated donor-acceptor quantum dot bilayer structure have been investigated …

From intracellular signaling to population oscillations: bridging size‐and time‐scales in collective behavior

AE Sgro, DJ Schwab, J Noorbakhsh… - Molecular systems …, 2015 - embopress.org
Collective behavior in cellular populations is coordinated by biochemical signaling networks
within individual cells. Connecting the dynamics of these intracellular networks to the …

Energy transfer from an individual silica nanoparticle to graphene quantum dots and resulting enhancement of photodetector responsivity

S Kim, DH Shin, J Kim, CW Jang, SS Kang, JM Kim… - Scientific reports, 2016 - nature.com
Förster resonance energy transfer (FRET), referred to as the transfer of the photon energy
absorbed in donor to acceptor, has received much attention as an important physical …

Knowledge-based design of long-chain arylpiperazine derivatives targeting multiple serotonin receptors as potential candidates for treatment of autism spectrum …

E Lacivita, M Niso, M Mastromarino… - ACS Chemical …, 2021 - ACS Publications
Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders
characterized by core symptoms such as impaired social interaction and communication …

H2O2-mediated modulation of cytosolic signaling and organelle function in rat hippocampus

FJ Gerich, F Funke, B Hildebrandt, M Faßhauer… - … -European Journal of …, 2009 - Springer
Reactive oxygen species (ROS) released from (dys-) functioning mitochondria contribute to
normal and pathophysiological cellular signaling by modulating cytosolic redox state and …

Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers

AS Hogendorf, A Hogendorf, K Popiołek-Barczyk… - European Journal of …, 2019 - Elsevier
The 5-HT 7 receptor has recently gained much attention due to its involvement in multiple
physiological functions and diseases. The insufficient quality of the available molecular …