Endothelial mechanobiology in atherosclerosis

X Wang, Y Shen, M Shang, X Liu… - Cardiovascular …, 2023 - academic.oup.com
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Hemodynamics and wall mechanics of vascular graft failure

JM Szafron, EE Heng, J Boyd… - … and Vascular Biology, 2024 - ahajournals.org
Blood vessels are subjected to complex biomechanical loads, primarily from pressure-driven
blood flow. Abnormal loading associated with vascular grafts, arising from altered …

Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia

H Bai, MA Varsanik, C Thaxton… - American Journal …, 2024 - journals.physiology.org
Clinical failure of arteriovenous neointimal hyperplasia (NIH) fistulae (AVF) is frequently due
to juxta-anastomotic NIH (JANIH). Although the mouse AVF model recapitulates human AVF …

RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68

Q Nie, X Wu, Y Huang, T Guo, J Kuang… - European Journal of …, 2023 - Springer
Purpose There is no report about the direct relationship between m6A modification and
androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the …

Adventitial injection of HA/SA hydrogel loaded with PLGA rapamycin nanoparticle inhibits neointimal hyperplasia in a rat aortic wire injury model

H Bai, H Wu, L Zhang, P Sun, Y Liu, B **e… - Drug Delivery and …, 2022 - Springer
Neointimal hyperplasia is a persistent complication after vascular interventions, and it is also
the leading cause of vascular graft restenosis and failure after arterial interventions, so novel …

Hydrogel-coated needles prevent puncture site bleeding

S Wei, Y Xu, Z Wang, M Li, P Sun, B **e, Y **ng, H Bai… - Acta Biomaterialia, 2021 - Elsevier
Introduction Incomplete hemostasis after vascular cannulation can cause a hematoma or
pseudoaneurysm. We hypothesized that a hydrogel-coated needle would effectively and …

Heme oxygenase 1/peroxisome proliferator‐activated receptor gamma pathway protects intimal hyperplasia and mitigates arteriovenous fistula dysfunction by …

T **e, Y Xu, L Ji, X Sui, A Zhang… - Cardiovascular …, 2022 - Wiley Online Library
Purpose. An arteriovenous fistula (AVF) is the preferred vascular access mode for
maintenance hemodialysis, and access stenosis and thrombosis are the primary causes of …

Early thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow

H Bai, Z Li, W Zhang, C Thaxton, Y Ohashi… - Journal of Thrombosis …, 2024 - Elsevier
Background Anticoagulation and antiplatelet therapy effectively inhibit neointimal
hyperplasia (NIH) in both arterial and venous systems but not in arteriovenous fistulae …

Comparative analysis of RADAR vs. conventional techniques for AVF maturation in patients with blood viscosity and vessel elasticity-related diseases through fluid …

P Wongchadakul, S Lohasammakul, P Rattanadecho - Plos one, 2024 - journals.plos.org
Purpose This study aims to compare two surgical techniques, the standard Vein-to-Artery
and the newer Artery-to-Vein (Radial Artery Deviation And Reimplantation; RADAR), for …

Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension?

M Tiezzi, H Deng, N Baeyens - Biochemical pharmacology, 2022 - Elsevier
The endothelium is a mechanosensitive organ whose pleiotropic actions regulate vessel
structure to adjust tissue perfusion. To do so, it possesses ion channels, receptor complexes …