Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While …

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …

MicroRNAs (miRNAs) are non-coding small RNAs that function as negative regulators of
gene expression involving in the tumor biology. ATP citrate lyase (ACLY), a key enzyme …

Abnormal lipid metabolism including synthesis, uptake, modification, degradation and
transport has been considered a hallmark of malignant tumors and contributes to the supply …

Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but
have also a key role as signaling molecules and in the modulation of epithelial cell …

Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …

Background Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly
attributing to its high tendency to metastasis. Vascular invasion provides a direct path for …

Carnitine palmitoyl transferase 1A (CPT1A) protein catalyzes the rate-limiting step of Fatty-
acid oxidation (FAO) pathway, which can promote cell proliferation and suppress apoptosis …

Dysregulation of pseudogenes, enhancement of fatty acid synthesis and formation of
immunosuppressive microenvironment are important factors that promote the malignant …

Abstract MicroRNA-22-3p (miR-22-3p) is downregulated in hepatocellular carcinoma (HCC),
which contributes to the development and progression of HCC. In this study, berberine …