Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is
involved in the development and progression of cardiovascular diseases. ROS are by …

Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2,
offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …

The heart is a highly structured organ consisting of different cell types, including myocytes,
endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides …

Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an
independent risk factor for death. Changes in the levels of uremic solutes or Klotho have …

Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …