Schizophrenia: an integrated sociodevelopmental-cognitive model
OD Howes, RM Murray - The Lancet, 2014 - thelancet.com
Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …
attempts to explain the pathogenic mechanisms of the disorder, and the …
Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk
P Fusar-Poli, M Tantardini, S De Simone… - European …, 2017 - cambridge.org
BackgroundSubjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability
to develop the disorder but the risk factors accounting for this accrued risk are undetermined …
to develop the disorder but the risk factors accounting for this accrued risk are undetermined …
The psychosis high-risk state: a comprehensive state-of-the-art review
Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …
Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and cross-sectional cohort studies
Evidence suggests that adverse experiences in childhood are associated with psychosis. To
examine the association between childhood adversity and trauma (sexual abuse, physical …
examine the association between childhood adversity and trauma (sexual abuse, physical …
Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk
Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …
psychotic disorder over time. However, the risk of transition to psychosis varies between …
The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological …
Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …
A critique of the “ultra‐high risk” and “transition” paradigm
The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …
Rethinking schizophrenia
TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …
disabling mental disorder that affects about one per cent of the world's population. After a …
Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis
Background: The current diagnostic system for subjects at enhanced clinical risk of
psychosis allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their …
psychosis allows concurrent comorbid diagnoses of anxiety and depressive disorders. Their …
Effect of ω-3 polyunsaturated fatty acids in young people at ultrahigh risk for psychotic disorders: the NEURAPRO randomized clinical trial
Importance A promising treatment to prevent onset and improve outcomes in patients at
ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated …
ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated …