Bipolar disorder is a recurrent chronic disorder characterised by fluctuations in mood state
and energy. It affects more than 1% of the world's population irrespective of nationality …

Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A
neurocognitive profile characterized by widespread cognitive deficits across multiple …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Objectives There is evidence that the gut microbiota plays a major role in the pathogenesis
of diseases of the central nervous system through the gut–brain axis. The aim of the present …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …

Background The neurotrophic hypothesis postulates that mood disorders such as bipolar
disorder (BD) are associated with a lower expression of brain-derived neurotrophic factor …

Illness staging is widely utilized in several medical disciplines to help predict course or
prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar …

We summarize evidence supporting contemporary pharmacological treatment of phases of
BD, including: mania, depression, and long-term recurrences, emphasizing findings from …

Importance The large contribution of psychiatric disorders to premature death and persistent
disability among young people means that earlier identification and enhanced long-term …