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Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …
Dietary fructose and the metabolic syndrome
Consumption of fructose, the sweetest of all naturally occurring carbohydrates, has
increased dramatically in the last 40 years and is today commonly used commercially in soft …
increased dramatically in the last 40 years and is today commonly used commercially in soft …
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
Metabolic changes of hepatocytes in NAFLD
Q Lu, X Tian, H Wu, J Huang, M Li, Z Mei… - Frontiers in …, 2021 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is often accompanied by systemic metabolic
disorders such as hyperglycemia, insulin resistance, and obesity. The relationship between …
disorders such as hyperglycemia, insulin resistance, and obesity. The relationship between …
[HTML][HTML] Elevated apoptosis in the liver of dairy cows with ketosis
Background/Aims: Dairy cows with ketosis are characterized by oxidative stress and hepatic
damage. The aim of this study was to investigate hepatic oxidative stress and the apoptotic …
damage. The aim of this study was to investigate hepatic oxidative stress and the apoptotic …
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
L Tuo, J **ang, X Pan, J Hu, H Tang, L Liang… - Journal of Experimental …, 2019 - Springer
Background Altered glucose metabolism endows tumor cells with metabolic flexibility for
biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in …
biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in …
[HTML][HTML] Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease
The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling
the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and …
the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and …
[HTML][HTML] Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
Objective Insulin resistance and altered hepatic mitochondrial function are central features
of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but the etiological …
of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but the etiological …
Ccne1 overexpression causes chromosome instability in liver cells and liver tumor development in mice
Background & Aims The CCNE1 locus, which encodes cyclin E1, is amplified in many types
of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected …
of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected …
Sex Differences in Nonalcoholic Fatty Liver Disease: Estrogen Influence on the Liver–Adipose Tissue Crosstalk
Significance: Nonalcoholic fatty liver disease (NAFLD) is a hepatic and systemic disorder
with a complex multifactorial pathogenesis. Owing to the rising incidence of obesity and …
with a complex multifactorial pathogenesis. Owing to the rising incidence of obesity and …