Decoding the brain: From neural representations to mechanistic models

MW Mathis, AP Rotondo, EF Chang, AS Tolias… - Cell, 2024 - cell.com
A central principle in neuroscience is that neurons within the brain act in concert to produce
perception, cognition, and adaptive behavior. Neurons are organized into specialized brain …

Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease

S Zhai, Q Cui, DNV Simmons, DJ Surmeier - Current opinion in …, 2023 - Elsevier
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …

Preparatory activity and the expansive null-space

MM Churchland, KV Shenoy - Nature Reviews Neuroscience, 2024 - nature.com
The study of the cortical control of movement experienced a conceptual shift over recent
decades, as the basic currency of understanding shifted from single-neuron tuning towards …

Lyapunov spectra of chaotic recurrent neural networks

R Engelken, F Wolf, LF Abbott - Physical Review Research, 2023 - APS
This article is part of the Physical Review Research collection titled Physics of
Neuroscience. Recurrent networks are widely used as models of biological neural circuits …

Hippocampome. org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits

DW Wheeler, JD Kopsick, N Sutton, C Tecuatl… - Elife, 2024 - elifesciences.org
Hippocampome. org is a mature open-access knowledge base of the rodent hippocampal
formation focusing on neuron types and their properties. Previously, Hippocampome. org v1 …

Rethinking the network determinants of motor disability in Parkinson's disease

DJ Surmeier, S Zhai, Q Cui… - Frontiers in Synaptic …, 2023 - frontiersin.org
For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical
determinant of network pathophysiology underlying the motor symptoms of Parkinson's …

Mind in vitro platforms: versatile, scalable, robust, and open solutions to interfacing with living neurons

X Zhang, Z Dou, SH Kim, G Upadhyay… - Advanced …, 2024 - Wiley Online Library
Motivated by the unexplored potential of in vitro neural systems for computing and by the
corresponding need of versatile, scalable interfaces for multimodal interaction, an accurate …

Simple decoding of behavior from a complicated neural manifold

SM Perkins, JP Cunningham, Q Wang, MM Churchland - BioRxiv, 2023 - biorxiv.org
Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen
to reflect scientific beliefs while yielding tractable computations. We document how low …

Control Principles of Neural Dynamics Revealed by the Neurobiology of Timing

GM Stine, M Jazayeri - Annual Review of Neuroscience, 2025 - annualreviews.org
Cognition unfolds dynamically over flexible timescales. A major goal of the field is to
understand the computational and neurobiological principles that enable this flexibility …

Representation of a perceptual bias in the prefrontal cortex

L Serrano-Fernández, M Beirán, R Romo… - Proceedings of the …, 2024 - pnas.org
Perception is influenced by sensory stimulation, prior knowledge, and contextual cues,
which collectively contribute to the emergence of perceptual biases. However, the precise …