Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction
and death, mainly through the overproduction of peroxides and the depletion of antioxidants …

Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted …

Impaired regulation of mitochondrial dynamics, which shifts the balance towards fission, is
associated with neuronal death in age-related neurodegenerative diseases, such as …

There is currently no approved neuroprotective pharmacotherapy for acute conditions such
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …

Acid-sensing ion channels (ASICs), newly discovered members of epithelial Na+
channels/degenirin superfamily, are widely distributed throughout the mammalian …

Ischemic stroke (IS) has complex pathological mechanisms, and is extremely difficult to treat.
At present, the treatment of IS is mainly based on intravenous thrombolysis and mechanical …

Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate
affinity. Its mechanism of action is neuroprotective and potentially therapeutic in several …

Glutamate toxicity involves increases in intracellular calcium levels and enhanced formation
of reactive oxygen species (ROS) causing neuronal dysfunction and death in acute and …

Memantine received marketing authorization from the European Agency for the Evaluation
of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer's …