The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …

The immunopeptidome is the set of peptides presented by the major histocompatibility
complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA) …

Peptide identification in liquid chromatography-tandem mass spectrometry (LC-MS/MS)
experiments relies on computational algorithms for matching acquired MS/MS spectra …

Traumatic injuries to the central nervous system (CNS) afflict millions of individuals
worldwide, yet an effective treatment remains elusive. Following such injuries, the site is …

Advances in mass spectrometry accelerates the characterization of HLA ligandome,
necessitating the development of efficient methods for immunopeptidomics analysis and …

Abstract The SysteMHC Atlas v1. 0 was the first public repository dedicated to mass
spectrometry-based immunopeptidomics. Here we introduce a newly released version of the …

The identification of T-cell epitopes is key for a complete molecular understanding of
immune recognition mechanisms in infectious diseases, autoimmunity and cancer. T-cell …

This review provides a comprehensive overview of the evolving landscape of cancer
vaccines, highlighting their potential to revolutionize tumor prevention. Building on the …

Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors
have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as …

Brain disorders represent a significant challenge in medical science due to the formidable
blood–brain barrier (BBB), which severely limits the penetration of conventional …