Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Single-pass membrane receptors contain extracellular domains that respond to external
stimuli and transmit information to intracellular domains through a single transmembrane …

Macrophages and microglia are implicated in several diseases with divergent roles in
physiopathology. This discrepancy can be explained by their capacity to endorse different …

Candida albicans causes severe invasive candidiasis. C. albicans infection requires the
virulence factor candidalysin (CL) which damages target cell membranes. However, the …

Eph receptor tyrosine kinases, together with their cell surface-anchored ephrin ligands,
constitute an important cell–cell communication system that regulates physiological and …

The Sam (sterile alpha motif) domain from the lipid phosphatase Ship2 binds the Sam
domain from the EphA2 receptor to negatively regulate receptor endocytosis and …

The impact of the EphA2 receptor on cancer malignancy hinges on the two different ways it
can be activated. EphA2 induces antioncogenic signaling after ligand binding, but ligand …

Bone sarcomas are malignant tumors of mesenchymal origin. Complete surgical resection is
the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms …

Transmembrane (TM) domains as simple as a single span can perform complex biological
functions using entirely lipid-embedded chemical features. Computational design has the …

Aim The purpose of this study was to investigate the function and mechanism of a novel
peptide derived from adipose‐derived stem cell‐conditioned medium (ADSC‐CM). Methods …