Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound
transcription factors that activate genes encoding enzymes required for synthesis of …

The standard treatment for high-grade serous ovarian cancer is primary debulking surgery
followed by chemotherapy. The extent of metastasis and invasive potential of lesions can …

Background Understanding the mechanisms of non-T cell inflamed tumor microenvironment
(TME) and their modulation are important to improve cancer immunotherapies such as …

Metabolic reprogramming is a central feature of transformed cells. Cancer metabolism is
now fully back in the focus of cancer research, as the interactions between oncogenic …

Lipids are essential cellular components and energy sources of living organisms, and
altered lipid composition is increasingly recognized as a signature of cancer. We performed …

The processes of cell proliferation, cell death and differentiation involve an intricate array of
biochemical and morphological changes that require a finely tuned modulation of metabolic …

Non-alcoholic steatohepatitis (NASH) is rapidly surpassing viral hepatitis as the primary
cause of hepatocellular carcinoma (HCC). However, understanding of NASH-progressed …

It has been 10 years since the concept of ferroptosis was put forward and research focusing
on ferroptosis has been increasing continuously. Ferroptosis is driven by iron-dependent …