Potential impact of the multi-target drug approach in the treatment of some complex diseases
It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …
disease burden faced by humankind. However, the rising global trends of the so-called …
Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …
economically active young adults, and has high mortality irrespective of HIV status. In some …
Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
The benzothiazinone BTZ043 is a tuberculosis drug candidate with nanomolar whole-cell
activity. BTZ043 targets the DprE1 catalytic component of the essential enzyme …
activity. BTZ043 targets the DprE1 catalytic component of the essential enzyme …
Tuberculosis: From an incurable scourge to a curable disease-journey over a millennium
SK Sharma, A Mohan - Indian Journal of Medical Research, 2013 - journals.lww.com
Globally, tuberculosis (TB) still remains a major public health problem. India is a high TB
burden country contributing to 26 per cent of global TB burden. During 1944-1980, TB …
burden country contributing to 26 per cent of global TB burden. During 1944-1980, TB …
Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host
A Schami, MN Islam, JT Belisle… - Frontiers in Cellular and …, 2023 - frontiersin.org
In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M. tb),
the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a …
the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a …
[PDF][PDF] The totally drug resistant tuberculosis (TDR-TB)
In 2009, we proposed the term “Totally Drug–Resistant Tuberculosis (TDR-TB)“for TB strains
that showed in-vitro resistance to all first and second line drugs tested (isoniazid, rifampicin …
that showed in-vitro resistance to all first and second line drugs tested (isoniazid, rifampicin …
Mycobacteriophages as potential therapeutic agents against drug-resistant tuberculosis
A Allué-Guardia, R Saranathan, J Chan… - International journal of …, 2021 - mdpi.com
The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …
Nanoparticle-Formulated Curcumin Prevents Posttherapeutic Disease Reactivation and Reinfection with Mycobacterium tuberculosis following Isoniazid Therapy
Curcumin, the bioactive component of turmeric also known as “Indian Yellow Gold,” exhibits
therapeutic efficacy against several chronic inflammatory and infectious diseases. Even …
therapeutic efficacy against several chronic inflammatory and infectious diseases. Even …
Discovery of New Inhibitors of Mycobacterium tuberculosis InhA Enzyme Using Virtual Screening and a 3D-Pharmacophore-Based Approach
Mycobacterium tuberculosis InhA (Mt InhA) is an attractive enzyme to drug discovery efforts
due to its validation as an effective biological target for tuberculosis therapy. In this work, two …
due to its validation as an effective biological target for tuberculosis therapy. In this work, two …
De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
Intracellular pathogens including Mycobacterium tuberculosis (Mtb) have evolved with
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …