Interactions between macromolecules, such as proteins and nucleic acids, are essential for
cellular functions. Experimental methods can fail to provide all the information required to …

Proteins play a crucial role in organisms in nature. They are able to perform structural,
catalytic, transport and defense functions in cells, among others. We understand that a …

Summary ATG9A and ATG2A are essential core members of the autophagy machinery.
ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer …

Signaling mediated by brain-derived neurotrophic factor (BDNF), which is supported by the
postsynaptic scaffolding protein PSD-95, has antidepressant effects. Conversely, clinical …

The immune checkpoint receptor lymphocyte activation gene 3 protein (LAG3) inhibits T cell
function upon binding to major histocompatibility complex class II (MHC class II) or …

G-quadruplexes (G4s) are four-stranded DNA secondary structures that occur in the human
genome and play key roles in transcription, replication, and genome stability. G4-specific …

The ideal vaccines for combating diseases that may emerge in the future require more than
simply inactivating a few pathogenic strains. This study aims to provide a peptide-based …

Summary Vγ9Vδ2 T cells play critical roles in microbial immunity by detecting target cells
exposed to pathogen-derived phosphoantigens (P-Ags). Target cell expression of BTN3A1 …

Structural, regulatory and enzymatic proteins interact with DNA to maintain a healthy and
functional genome. Yet, our structural understanding of how proteins interact with DNA is …

Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …