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Novel 1, 2, 4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies
A series of novel compounds carrying 1, 2, 4-triazole scaffold was synthesized and
evaluated for their anticancer activity against a panel of cancer cell lines using MTT assay …
evaluated for their anticancer activity against a panel of cancer cell lines using MTT assay …
Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A2A Receptor
Classical drug design and development rely mostly on affinity‐or potency‐driven structure–
activity relationships (SAR). Thus far, a given compound's binding kinetics have been largely …
activity relationships (SAR). Thus far, a given compound's binding kinetics have been largely …
Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5, 6-dihydro-5-azapurines
We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,
6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The …
6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The …
Base-promoted aerobic oxidative synthesis of fused 1, 3, 5-triazines under metal-free conditions
J Chen, Z Sun, F **ao, GJ Deng - Green Chemistry, 2020 - pubs.rsc.org
An efficient base-promoted aerobic oxidation reaction for the synthesis of fused 1, 3, 5-
triazines from 2-aminobenzimidazoles, aromatic aldehydes, and ammonium iodide has …
triazines from 2-aminobenzimidazoles, aromatic aldehydes, and ammonium iodide has …
A novel multicomponent microwave-assisted synthesis of 5-aza-adenines
A novel multicomponent strategy for the efficient synthesis of 5-aza-adenines was
developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1, 2, 4 …
developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1, 2, 4 …
Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6, 7-dihydro [1, 2, 4] triazolo [1, 5-a][1, 3, 5] triazin-5-amines
In our lead finding program, 12 new fluorinated 7-aryl-2-pyridyl-6, 7-dihydro [1, 2, 4] triazolo
[1, 5-a][1, 3, 5] triazin-5-amines were prepared via a practical three-step procedure starting …
[1, 5-a][1, 3, 5] triazin-5-amines were prepared via a practical three-step procedure starting …
A convenient method for the synthesis of 7-amino-substituted 1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazin-5-amines
A new practical synthesis of 7-amino-substituted 1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazin-5-
amines is developed. The triazine ring closure of 5-guanidino-3-phenyl-1, 2, 4-triazole with …
amines is developed. The triazine ring closure of 5-guanidino-3-phenyl-1, 2, 4-triazole with …
A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazines
A new, efficient, catalyst-free, one-pot, three-component method for the synthesis of 2-amino-
substituted 7-amino-1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazines using 3, 5-diamino-1, 2, 4 …
substituted 7-amino-1, 2, 4-triazolo [1, 5-a][1, 3, 5] triazines using 3, 5-diamino-1, 2, 4 …
3-Dialkylamino-1,2,4-triazoles via ZnII-Catalyzed Acyl Hydrazide–Dialkylcyanamide Coupling
Zinc (II)-catalyzed (10 mol% ZnCl2) coupling of acyl hydrazides and dialkylcyanamides in
ethanol leads to 3-dialkylamino-1, 2, 4-triazoles (76–99%; 17 examples). This reaction …
ethanol leads to 3-dialkylamino-1, 2, 4-triazoles (76–99%; 17 examples). This reaction …
Copper-catalyzed tandem reactions of 2-amine-[1, 3, 5] triazines with nitriles
LY Zhang, C Zhang, T Wang, YL Shi… - The Journal of …, 2018 - ACS Publications
Copper-catalyzed intermolecular annulation of 2-amine-[1, 3, 5] triazines and aryl nitriles for
the synthesis of [1, 2, 4] triazolo [1, 5-a][1, 3, 5] triazines via N–C bond formation and …
the synthesis of [1, 2, 4] triazolo [1, 5-a][1, 3, 5] triazines via N–C bond formation and …