Hydrogels present versatile platforms for the encapsulation and delivery of proteins and
cells for regenerative medicine applications. However, differences in hydrogel cross-linking …

Background Trials of a vaginal Tenofovir gel for pre-exposure prophylaxis (PrEP) for HIV
have given conflicting results. Knowledge of concentrations of Tenofovir and its active form …

Diffusion through biological gels is crucial for effective drug delivery using nanoparticles.
Here, we demonstrate a new method to measure diffusivity over a large range of length …

Topical antimicrobials, or microbicides, are being developed to prevent HIV transmission
through local, mucosal delivery of antiviral compounds. While hydrogel vehicles deliver the …

The prophylactic activity of antiretroviral drugs applied as microbicides against sexually
transmitted HIV is dependent upon their concentrations in infectable host cells. Within …

Confocal Raman spectroscopy was implemented in a new label-free technique to quantify
molecular diffusion coefficients within gels. A leading anti-HIV drug, tenofovir, was analyzed …

Topical microbicide products are being developed for the prevention of sexually transmitted
infections. These include vaginally-applied gels that deliver anti-HIV molecules. Gels may …

There is a widespread agreement that more effective drug delivery vehicles with more
alternatives, as well as better active pharmaceutical ingredients (APIs), must be developed …

The diffusion behavior of poly (ethylene glycol)(PEG) in N-isopropylacrylamide (NIPAAm)
hydrogels was investigated using confocal Raman spectroscopy with regard to temperature …

Although a number of drugs have been developed for the treatment and prevention of
human immunodeficiency virus (HIV) infection, it has proven difficult to optimize the drug and …