Natural killer cell biology: an update and future directions
KS Campbell, J Hasegawa - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Natural killer (NK) cells constitute a minor subset of normal lymphocytes that initiate innate
immune responses toward tumor and virus-infected cells. They can mediate spontaneous …
immune responses toward tumor and virus-infected cells. They can mediate spontaneous …
Control of human viral infections by natural killer cells
S Jost, M Altfeld - Annual review of immunology, 2013 - annualreviews.org
Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1
Blockade of the PD1 pathway is a broadly effective cancer therapy, but additional immune-
inhibitory pathways contribute to tumor immune evasion. HERV–H LTR-associating 2 …
inhibitory pathways contribute to tumor immune evasion. HERV–H LTR-associating 2 …
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target
The B7 family ligand HERV-H LTR–associating protein 2 (HHLA2) is an attractive target for
cancer immunotherapy because of its coinhibitory function, overexpression in human …
cancer immunotherapy because of its coinhibitory function, overexpression in human …
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
Type I interferons are important in regulating immune responses to pathogens and tumors.
All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet …
All interferons are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet …
Modulation of innate and adaptive immunity by cytomegaloviruses
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
against viruses. To counter this, some viruses have evolved sophisticated strategies to …
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1
The activating natural killer (NK)-cell receptor KIR3DS1 has been linked to the outcome of
various human diseases, including delayed progression of disease caused by human …
various human diseases, including delayed progression of disease caused by human …
Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
J Robinson, LA Guethlein, N Cereb, SY Yang… - PLoS …, 2017 - journals.plos.org
HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage
lymphocyte receptors. Recently, clinical application of sequence-based HLA ty** has …
lymphocyte receptors. Recently, clinical application of sequence-based HLA ty** has …
Crystal structure of the human LAG-3–HLA-DR1–peptide complex
J Petersen, C Llerena, B Golzarroshan, C Faoro… - Science …, 2024 - science.org
T cell activity is governed by T cell receptor (TCR) signaling and constrained by immune
checkpoint molecules, including programmed cell death protein 1 (PD-1), cytotoxic T …
checkpoint molecules, including programmed cell death protein 1 (PD-1), cytotoxic T …
Structure of the TAPBPR–MHC I complex defines the mechanism of peptide loading and editing
C Thomas, R Tampé - Science, 2017 - science.org
Adaptive immunity is shaped by a selection of peptides presented on major
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …