Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic
alterations in epigenetic regulators. This includes missense mutations in histones, which …

The intestinal microbiota is a community of microorganisms inhabiting the human intestines,
potentially influencing both physiological and pathophysiological processes in the human …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

Abstract N6-methyladenosine (m6A) is the most prevalent RNA modification at the
posttranscriptional level and involved in various diseases and cellular processes. However …

FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear
ribonucleoprotein family, have gained significant attention in the field of neurodegenerative …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …