Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

The young circulatory milieu capable of delaying aging in individual tissues is of interest as
rejuvenation strategies, but how it achieves cellular-and systemic-level effects has remained …

The function of somatic stem cells declines with age. Understanding the molecular
underpinnings of this decline is key to counteract age-related disease. Here, we report a …

The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …

Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Aging is associated with impaired hematopoietic and immune function caused in part by
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …