Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

During the past two decades, invasive fungal infections have emerged as a major threat to
immunocompromised hosts. Patients with neoplastic diseases are at significant risk for such …

Neutrophils are the first line of defense at the site of an infection. They encounter and kill
microbes intracellularly upon phagocytosis or extracellularly by degranulation of …

Opportunistic pathogens have become of increasing medical importance over the last
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …

Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly
meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected …

Recently, proinflammatory activities had been described for S100A8 and S100A9, two
proteins found at inflammatory sites and within the neutrophil cytoplasm. In this study, we …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

Background Exosomes are nano-sized extracellular vesicles participating in cell-to-cell
communication both in health and disease. However, the knowledge about the functions …

Cryptococcus species, the etiological agents of cryptococcosis, are encapsulated fungal
yeasts that predominantly cause disease in immunocompromised individuals, and are …

The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …