Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming

TY Du, SR Hall, F Chung, S Kurdyukov… - Science Translational …, 2024 - science.org
Snakebites affect about 1.8 million people annually. The current standard of care involves
antibody-based antivenoms, which can be difficult to access and are generally not effective …

Proteogenomic approaches for snake venom protein-based drug development: current trends and challenges

SK Jhade, K Kalidoss, PK Pathak… - Transactions of The …, 2025 - academic.oup.com
Snake venom proteins have long been recognized for their therapeutic potential.
Proteogenomic strategies, integrating transcriptomics and proteomics, have emerged as …

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These …

PV Dubovskii, YN Utkin - Toxins, 2024 - mdpi.com
Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom.
Our analysis of the available CT amino acid sequences, literature data on their membrane …

[HTML][HTML] Venom variation among the three subspecies of the north African mountain viper Vipera monticola Saint Girons 1953

M Damm, I Avella, R Merzara, N Lucchini, J Buldain… - Biochimie, 2024 - Elsevier
Abstract The North African mountain viper (Vipera monticola) is a medically relevant
venomous snake distributed in Morocco, Algeria, and Tunisia. Three subspecies of V …

Pulmonary thromboembolism following Russell's viper bites

S Senthilkumaran, S Sampath, JR Almeida, J Williams… - Toxins, 2024 - mdpi.com
Snakebite envenoming and its resulting complications are serious threats to the health of
vulnerable people living in rural areas of develo** countries. The knowledge of the …

Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules

MA Bittenbinder, F Bonanini, D Kurek, P Vulto… - Scientific Reports, 2024 - nature.com
Snakebite envenomation is a major public health issue which causes severe morbidity and
mortality, affecting millions of people annually. Of a diverse range of clinical manifestations …

Snakebite-associated acute kidney injury in South Asia: narrative review on epidemiology, pathogenesis and management

BY Alvitigala, LV Gooneratne… - Transactions of The …, 2025 - academic.oup.com
Snakebite-associated acute kidney injury (AKI) poses a significant health burden in the
South Asia region, resulting in considerable morbidity and mortality. Multiple factors …

A simple method to determine proteolytic activity of snake venoms

F Camicia, RI Miguez, NR Lago, CF Damin… - Toxicon, 2024 - Elsevier
In this work, we describe an easy, simple, and cost-effective method to assess the proteolytic
activity of snake venoms. The method is based on measuring the hydrolytic halo formed by …

Dermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon

FB Albuquerque Barbosa, RS Raad… - PLOS Neglected …, 2024 - journals.plos.org
Background Bothrops venom consists primarily of metalloproteinase and phospholipase A2
toxins, which are responsible for the acute inflammatory, coagulant and hemorrhagic action …

Categorization and Characterization of Snake Venom Variability through Intact Toxin Analysis by Mass Spectrometry

LL Alonso, J Slagboom, NR Casewell… - Journal of Proteome …, 2025 - ACS Publications
The variation in venom between and within snake species has significant implications for
snakebite treatment. This highlights the critical importance of studying venom composition …