The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas
Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …
Immune suppression in head and neck cancers: a review
A Duray, S Demoulin, P Hubert… - Journal of …, 2010 - Wiley Online Library
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in
the world. Despite significant advances in the treatment modalities involving surgery …
the world. Despite significant advances in the treatment modalities involving surgery …
PD-1–expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer
C Badoual, S Hans, N Merillon, C Van Ryswick… - Cancer research, 2013 - AACR
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable
clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We …
clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We …
An oncolytic virus–delivered tgfβ Inhibitor overcomes the immunosuppressive tumor microenvironment
K DePeaux, DB Rivadeneira, K Lontos… - Journal of Experimental …, 2023 - rupress.org
While checkpoint blockade immunotherapies have widespread success, they rely on a
responsive immune infiltrate; as such, treatments enhancing immune infiltration and …
responsive immune infiltrate; as such, treatments enhancing immune infiltration and …
During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
E Pylaeva, G Korschunow, I Spyra, S Bordbari… - Cell Reports, 2022 - cell.com
Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation
of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs …
of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs …
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated …
worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated …
APOBEC3A functions as a restriction factor of human papillomavirus
Human papillomaviruses (HPVs) are small DNA viruses causally associated with benign
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …
Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV+ oral cancer
Background The US is experiencing an epidemic of HPV+ oropharyngeal cancers (OPC),
the rates and burden of which now exceed that for cervical cancer. Immunotherapy targeting …
the rates and burden of which now exceed that for cervical cancer. Immunotherapy targeting …
[HTML][HTML] Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal
D Liang, H **ao-Feng, D Guan-Jun, H Er-Ling… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The negative role of the activated stimulator of IFN genes (STING) has been uncovered in
autoinflammatory disease and cancer. However, the role of STING in virus-related …
autoinflammatory disease and cancer. However, the role of STING in virus-related …
Mouse tumor-bearing models as preclinical study platforms for oral squamous cell carcinoma
Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …