Granuloma formation in pulmonary sarcoidosis

CE Broos, M van Nimwegen, HC Hoogsteden… - Frontiers in …, 2013 - frontiersin.org
Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …

[HTML][HTML] Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

T Krausgruber, A Redl, D Barreca, K Doberer… - Immunity, 2023 - cell.com
Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …

The lymphatic vasculature in lung function and respiratory disease

A Trivedi, HO Reed - Frontiers in Medicine, 2023 - frontiersin.org
The lymphatic vasculature maintains tissue homeostasis via fluid drainage in the form of
lymph and immune surveillance due to migration of leukocytes through the lymphatics to the …

Mathematical model of sarcoidosis

W Hao, ED Crouser, A Friedman - Proceedings of the National Academy of …, 2014 - pnas.org
Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming
nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph …

[HTML][HTML] Histology of cardiac sarcoidosis with novel considerations arranged upon a pathologic basis

S Kato, Y Sakai, A Okabe, Y Kawashima… - Journal of Clinical …, 2022 - mdpi.com
Sarcoidosis is a rare disease of isolated or diffuse granulomatous inflammation. Although
any organs can be affected by sarcoidosis, cardiac sarcoidosis is a fatal disorder, and it is …

Lymphatic changes in respiratory diseases: more than just remodeling of the lung?

B Stump, Y Cui, P Kidambi, AM Lamattina… - American journal of …, 2017 - atsjournals.org
Advances in our ability to identify lymphatic endothelial cells and differentiate them from
blood endothelial cells have led to important progress in the study of lymphatic biology. Over …

Hypoxia promotes a mixed inflammatory-fibrotic macrophages phenotype in active sarcoidosis

F Jeny, JF Bernaudin, D Valeyre… - Frontiers in …, 2021 - frontiersin.org
Background Macrophages are pivotal cells in sarcoidosis. Monocytes-derived (MD)
macrophages have recently been demonstrated to play a major role especially in pulmonary …

The Lymphatic Vasculature in Lung Homeostasis and Disease

K Maisel, H Outtz Reed - Annual Review of Physiology, 2024 - annualreviews.org
The lymphatic vasculature maintains lung homeostasis via fluid drainage in the form of
lymph and by facilitating immune surveillance and leukocyte trafficking to the draining lymph …

Advances in cellular and tissue-based imaging techniques for sarcoid granulomas

J Kim, G Dwivedi, BA Boughton… - American Journal of …, 2024 - journals.physiology.org
Sarcoidosis embodies a complex inflammatory disorder spanning multiple systems, with its
origin remaining elusive. It manifests as the infiltration of inflammatory cells that coalesce …

Pulmonary sarcoidosis

D Valeyre, JF Bernaudin, F Jeny… - Clinics in chest …, 2015 - chestmed.theclinics.com
Sarcoidosis is a systemic disease affecting the lung in almost all cases. 1–3 Whatever the
various revealing symptoms, the evidence of abnormal chest radiography is usually a key …